This topic contains 7 replies, has 5 voices, and was last updated by Virginia Seery January 5, 2018 at 2:54 am.

Viewing 8 posts - 1 through 8 (of 8 total)
  • Author
    Posts
  • #4570

    Have you seen any instances of ocular herpes in a T-VEC treated patient?

    #4576
    Expert Nurse
    Krista Rubin
    Krista Rubin

    I have not; though admittedly our experience with T-Vec is fairly limited at this time.

    #4579
    Expert Nurse
    Virginia Seery
    Virginia Seery

    I have not seen any ocular herpes and we have been doing T-VEC routinely for about two years. I have had two patients develop occasional canker sores during therapy, but both of them had a history of this before starting T-VEC.

    #4583
    Expert Nurse
    Kathleen Madden
    Kathleen Madden

    We too have had limited experience with T-VEC but of those patients, the only AE’s we observed were more consistent with flu like symptoms which were treated with benadryl, acetaminophen & sometimes prednisone, but typically for the first 24 hours after the injection. Regarding ocular herpes, my experiences with this is a compication typically associated with an outbreak of shingles along the ophthalmic or maxiallary dermatome which has impacted the eye, but none of these were related to T-Vec. It is possible to aquire a localized herpetic infection from other sources of contact.

    #4588
    Expert Nurse
    Krista Rubin
    Krista Rubin

    Curious to hear how others would handle:

    Would your practice consider TVEC for a patient with a HISTORY OF recurrent herpetic infections (including ocular) that required daily suppression?

    #4589
    Expert Nurse
    Lisa Kottschade
    Lisa Kottschade

    Hi Krista-

    That is a very interesting question. I think this would be a difficult situation and I would want to reserve this treatment for a setting where other therapies have failed. I would not absolutely rule it out.

    #4596
    Expert Nurse
    Krista Rubin
    Krista Rubin

    Thanks Lisa. The patient has lesions that are ideal to inject…but the ocular herpes history makes me nervous. Other options are being explored.

    #4599
    Expert Nurse
    Virginia Seery
    Virginia Seery

    Krista, my hesitation would be the need for chronic suppression with antivirals as this could potentially decrease the efficacy of T-VEC. However, if other options are limited or exhausted, it would be reasonable to consider with close monitoring for recurrent ocular symptoms.

Viewing 8 posts - 1 through 8 (of 8 total)

You must be logged in to reply to this topic.