This topic contains 2 replies, has 2 voices, and was last updated by Krista Rubin January 27, 2018 at 11:50 pm.

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  • #4623
    Expert Nurse
    Krista Rubin
    Krista Rubin

    Has anyone had a patient report “ear fullness” with combo dabrafenib and trametinib or vemurafenib and cobimetinib? Pt describes it as feeling like her ears are clogged- but on exam, no wax and TMs look normal. She is quite bothered by it.

    Thanks

    #4624
    Expert Nurse
    Virginia Seery
    Virginia Seery

    I have not had patients complain of ear symptoms while on these agents. Lots of other side effects, but not this one! How will you manage this? ENT referral or ride it out?

    #4628
    Expert Nurse
    Krista Rubin
    Krista Rubin

    So- I had success with a daily cetirizine. It is possible she may have had a mild URI, or similar- but she experienced it both on dabrafenib + trametinib AND vem/cobi (which we needed to switch to for unrelated reasons).

    Thank you for your reply Virginia I’ll let you know for get any more!

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