Grading of Infusion Reaction

Mild, transient reaction; infusion interruption not indicated; intervention not indicated

Management

Checkpoint inhibitor: For mild/moderate (Grade 1-2) reactions: interrupt or slow rate of infusion; monitor to recovery
For severe/life-threatening (Grade 3-4) reactions: Discontinue nivolumab and/or ipilimumab; manage anaphylaxis via institutional protocol; monitor. Premedication with an antipyretic and antihistamine may be considered for future doses