Pembro plus Epacadostat - The Melanoma Nursing Initiative

This topic has 8 replies, 6 voices, and was last updated June 11, 2018 at 2:29 pm by Anonymous.

Viewing 9 posts - 1 through 9 (of 9 total)

Author

Posts
April 13, 2018 at 5:10 pm #4805
Anonymous
What are your thoughts on the Phase III trial with pembro plus Epacadostat not reaching its endpoint? I feel like we had a lot of patients that did quite well on it, though I suppose those might be the patients that would have responded just as well to single agent PD-1. Have you all had a lot of questions about this trial from patients?
April 20, 2018 at 2:56 am #4813
Anonymous
Surprisingly, we have not had many patients asking us about this trial. I know going into it there was a lot of excitement about the combination so we were surprised it did not reach its endpoint.
April 20, 2018 at 11:08 pm #4814
Anonymous
Yeah…..I guess we still had patients on it in the phase 1 setting that were eager. They’ve obviously done well if still on it in Phase 1, but I think some of them were hoping it would be approved so they could get through local oncologist.
April 25, 2018 at 10:09 pm #4819
Anonymous
The results of this trial were quite striking, especially with strong Phase I/II data. There is some thought that the dose of the IDO inhibitor may have been too low. Was very disappointing as this may have been a good alternative to dual ICI therapy in those that tolerability was questionable.
April 26, 2018 at 12:01 am #4820
Anonymous
We have been spoiled lately; in that so many treatment options for melanoma have become available in the recent years. We have not been disappointed by trial results in quite a while (thankfully). Perhaps this is a reminder to all of us that indeed, melanoma remains a difficult to treat malignancy.
April 27, 2018 at 11:25 pm #4825
Anonymous
So true! We have been SO fortunate to have gained such ground in melanoma over the last several years!
May 11, 2018 at 9:49 pm #4835
Anonymous
We’re now having to notify patients that the trial didn’t reach its endpoint and take them off the IDO. This is really tough for those patients that have been on this in Phase 1 for quite some time……especially considering that some did REALLY WELL!
June 10, 2018 at 4:40 am #4849
Samantha Guild
We were just discussing this last week. After years of ASCO having huge announcements of positive very influential findings things have slowed down. With the discovery of Ipilimumab and Nivolumab and the BRAF/MEK inhibitors we are almost at a plateau when it comes to new innovations. I am sure there are many more to come but at the moment especially front line clinical trials seems to be limited.
June 11, 2018 at 2:29 pm #4850
Anonymous
Rajni–
such a good point.
In the melanoma world, we have been lulled into this sense that every year there will be new treatments for melanoma. The last five years have been amazing, with so many new therapies and new combinations of therapies that have truly changed the way we manage melanoma. This year was the first in which it seemed like it slowed down.
Author

Posts

Viewing 9 posts - 1 through 9 (of 9 total)

You must be logged in to reply to this topic.

Login

Latest Activity