We do not routinely premedicate either unless with the first or a subsequent dose there have been adverse events experienced. When we do premed and manage post injection sx we typically use tylenol or ibuprofen and benadryl 25mg since the gmcsf component often creates a cytokine release which causes the elevated temps and chills / flu-like sx.
We will have a patient premed day of, then remedicate every 8 hours for up to 48 hours as needed, but definitely the first 24 hours. On a very rare occassion we have use low dose dex for a pt who atypically went up to 105, he was on concurrent pembro.
Suzanne, great spotlight on ICI induced AI- thank you for that reminder!