Tissue availability is a large barrier for BRAF testing especially in patients with microscopic foci in a single lymph node. Often times there isn’t enough tissue to test. In these patients we often have to wait and see and if they end up with progressio. Of disease, they have to undergo procedure to procure more tissue. Patient often find distress in this process for they just have found out they have recurrent disease and now have to undergo a procedure for tissue for BRAF testing. If we can we try to at least do a IHC on tissue to see if we can get BRAF results.