In my practice I have had patients experience fevers of up to 105, that is not the norm though, most patients experienced fevers up to 101-103. We try to prevent such high fevers by having patients notify the treating office at the onset of any adverse events.
However, the newer braf/ mek combination encorafenib & binimetinib during clinical trials demonstrated and 18% rate of pyrexia, lower incidence than other braf mek combinations. This may be a good alterantive to another combination, if pyrexia is a dose or treatment limiting side effect.
Thank you for your input and questions, Morgan.