Thank you Kathy for this great reply. It’s very helpful. I’ll definitely bring up the topic of the new dosing regimen as per the article posted.

I’ve got one more question regarding dosing of nivo that you could possibly clarify. If “patient’s A” weight (currently at 90kg) goes down at some point by let’s say 2kg would that warrant change of dosing straight away i.e. lowering it by 6g to 264mg total or would the change in weight need to be more substantial in order to justify change of current dose? Thank you.