I have had several patients with ICI related sensorial hearing loss due to nerve inflammation & irritation, steroids were helpful but it was the combination of steroids & time that reversed this irAE.

However, I have 1 paient who has been off ici therapy due to pod transitioned to braf/mek therapy for > 6months and developed acute neurological sx about 12 weeks post ICI therapy. Sx consisted of vertigo, headache, vision changes with no brain metastases. she has been on & off steroids for months. She has been seen by ENT & has recently been receiving steroid injections into her ears for labrynthitis.Her most recent mri confirmed this & no presence of brain metastases.

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