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  • #4777
    Anonymous

      Has anyone seen severe hypercalcemia on patients treated with Ipi/Nivo? We have a patient from our team in the ICU right now with a calcium of 18, only has one bone metastasis, so clinical picture does not fit well. I see there are a couple of case reports in the literature, but nothing this severe.

      Thank you!
      Lisa

      #4778
      Anonymous

        Lisa,
        I have not seen severe hypercalcemia on the ipi/nivo combination. A calcium of 18 is certainly not subtle; I hope your patient does OK. Anyone else?

        #4782
        Anonymous

          Oh, wow! We have not seen this either. It sounds like it could be from an autoimmune process, though. Have you all utilized steroids yet? Keep us posted on how this evolves. Very interested. I hope that it turns out well for the patient involved.

          #4784
          Anonymous

            We have not seen this either,yes, please keep us apprised of how your patient is doing. Hoping that they’ve already improved.

            #4785
            Anonymous

              Thank you all. Unfortunately despite early intervention with steroids, dialysis, and PLEX, and getting the calcium down the patient passed away a couple of days ago. Very sad. We still really don’t have a cause, paraneoplastic panel was essentially negative.

              #4793
              Anonymous

                So sorry to hear this outcome, Lisa, thank you for letting us know.

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