Has anyone seen severe hypercalcemia on patients treated with Ipi/Nivo? We have a patient from our team in the ICU right now with a calcium of 18, only has one bone metastasis, so clinical picture does not fit well. I see there are a couple of case reports in the literature, but nothing this severe.
Oh, wow! We have not seen this either. It sounds like it could be from an autoimmune process, though. Have you all utilized steroids yet? Keep us posted on how this evolves. Very interested. I hope that it turns out well for the patient involved.
Thank you all. Unfortunately despite early intervention with steroids, dialysis, and PLEX, and getting the calcium down the patient passed away a couple of days ago. Very sad. We still really don’t have a cause, paraneoplastic panel was essentially negative.