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  • #4734
    Expert Nurse
    Krista Rubin

    At your centers, is infliximab being used to treat steroid refractory pneumonitis? If so, what has the experience been?
    Thank you

    #4735
    Expert Nurse
    Kathleen Madden

    No, Krista, we have been fortunate enough that even our most severe cases of pneumonitis have responded to high dose steroids, but I could see how the thought consideration could come up.
    I suppose that we may in that instance consider temsirolimus or another anti-rejection med, which would be utilized with a patient who had a lung transplant- like we do with mycophenalate & irAE related hepatitis.

    -Kathy

    #4740
    Expert Nurse
    Suzanne McGettigan

    Hi Krita–
    We have utilized infliximab for a number of steroid-refractory immune related toxicities, including pneumonitis and myocarditis.
    For hepatitis, we do not use infliximab and have used mycophenylate in the steroid-refractory setting.

    #4748
    Expert Nurse
    Kathleen Madden

    Suzanne, you make a good point that infliximab should not be administered for immune hepatitis, in the literature, this is noted as a contraindication due to it’s own potential for hepatotoxicity.

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