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  • #4734
    Anonymous

      At your centers, is infliximab being used to treat steroid refractory pneumonitis? If so, what has the experience been?
      Thank you

      #4735
      Anonymous

        No, Krista, we have been fortunate enough that even our most severe cases of pneumonitis have responded to high dose steroids, but I could see how the thought consideration could come up.
        I suppose that we may in that instance consider temsirolimus or another anti-rejection med, which would be utilized with a patient who had a lung transplant- like we do with mycophenalate & irAE related hepatitis.

        -Kathy

        #4740
        Anonymous

          Hi Krita–
          We have utilized infliximab for a number of steroid-refractory immune related toxicities, including pneumonitis and myocarditis.
          For hepatitis, we do not use infliximab and have used mycophenylate in the steroid-refractory setting.

          #4748
          Anonymous

            Suzanne, you make a good point that infliximab should not be administered for immune hepatitis, in the literature, this is noted as a contraindication due to it’s own potential for hepatotoxicity.

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