- Is there a pre-existing autoimmune dysfunction?
- Is there a history of prior orthopedic injury, DJD, OA, RA?
- Other immune-related adverse effects
- Three subtypes of inflammatory arthritis associated with checkpoint inhibitors:
- Polyarthritis similar to rheumatoid arthritis
- True reactive arthritis with conjunctivitis, urethritis, and oligoarthritis
- Subtype similar to seronegative spondyloarthritis with inflammatory back pain and predominantly larger joint involvement
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